Correlation between serum albumin and initial GCS in patient with head injury in a tertiary hospital

Abstract

Introduction: Traumatic brain injury(TBI) is a major cause of disability, death and economic burden to the society.Albumin is a major protein of human. Values fall as a component of metabolic response to injury or infection.Albumin being a negative phase reactant is consumed under states of stress such as TBI.Materials and Methods: This is a descriptive observational study conducted at the Department of Surgery,TUTH over a period of 1 year between 2014 and 2015. Albumin level at admission was correlated with severityof head injury, Glasgow Coma Scale at admission and duration of hospital stay.Results: Among 59patients with isolated TBI patients from TUTH, 40(68%) were male and 19(32%) were female.55% of head injuries occurred between the ages of 18-40 years. Out of total patients, fall was the major causeof head injury with 24 (41%) under this category. Nine (15%) had severe head injury; 22 (37%) had moderateand 28 (47.45%) patients had severe head injury at admission. Contusion 19 (28%) and subdural hematoma17(26%) were the predominant computed tomography findings. Twenty four (40%) patients were managedconservatively, thirty five (60%) patients were operated. The average albumin level at admission for patientswith mild, moderate and severe head injury were 41,46gm/dl , 33.76gm/dl , 31.1gm/dl respectively. There is apositive correlation between initial serum albumin and GCS at admission (p=0.01, R= 0.747).Conclusion: There is a positive correlation between initial serum albumin and GCS at admission. Further researchon this topic at multiple centres is warranted.