An institutional review of tumour biology of breast cancer in young Nepalese women

  • Bikash Nepal
  • Yogendra Singh
  • Prakash Sayami
  • Gita Sayami


Introduction: Breast cancers in <40 years of age group usually presents with aggressive biology and has poor prognosis. The aim of this study was to see clinic-pathological and hormone receptors of breast cancers in young women and compare with less than 40 year age group.Methods : Prospective analysis of 97 breast cancer in patients less than 40 years out of total 373 patients (26%) over a period of 8 years (2007 Jan to 2014 Dec) was carried out at the Department of Surgery, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.Result: Among the young women diagnosed with breast cancer, the mean age was 34.5±6.2 years. Mean tumour size was larger in younger women (5±2.5 vs 4.5±2.4 cm). Locally advanced disease was higher in younger patients (55% vs 47%). Lymphatic and vascular invasions were higher (63% vs 35% and 40% vs 25%). Grade II and  III tumours was higher (56% vs 25%). ER, PR and HER2 positivity was detected in 46.9%, 48.9% and 28.9%, respectively. Significant lower ER/or PR expression (34.5% vs 54%) was seen in younger women, p=.002.Triple negative tumours (ER-, PR- and HER2-ve) was proportionately higher in younger patients (23% vs 13.7%, p=.043).Conclusions: Young Nepalese women presents one quarter of all female breast cancers, more frequently locally advanced with aggressive tumour biology like ER/PR negative and triple negative breast cancers.


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How to Cite
NEPAL, Bikash et al. An institutional review of tumour biology of breast cancer in young Nepalese women. J Soc Surg Nep, [S.l.], v. 18, n. 2, p. 16-19, aug. 2017. ISSN 2392-4772. Available at: <>. Date accessed: 24 feb. 2021.
Original Article