A single institutional experience of surgically resected Thymomas– Clinicopathological analysis
AbstractIntroduction: Epithelial thymic tumours (ett), which comprise the majority of thymomas, are neoplasias developed from the epithelial cells of the thymus and constitute around 30% of anterior mediastinal masses in adults. This study aims at analyzing the clinicopathological aspects of thymomas encountered in a single thoracic surgical unit.Material and methods: a retrospective analysis of prospectively maintained data of thymoma diagnosed and treated in the thoracic surgery unit of the austin hospital from 1992-2010.Results: forty –eight patients were operated for thymomas in the mentioned duration. The ages ranged from 22-86 years with a mean age of 54.47 With a peak in the 51-70 years age group. Twelve of the 48 patients (25%) had presented with myaesthenia gravis of the 29 cases which were diagnosed after 1999 (post introduction of new who classi" cation), there were three cases of type a, three of ab, eight of b1, six of b2, ten of b3. There were also two cases of mixed b1+ b2 and six of mixed b2+ b3 histologies. Sixty –four percentage of the tumours were masaoka Stage II , 21% of stage I, 10.5% of stage III and 3.5% of stage IV a. Surgery was used as the primary modality of treatment, six of these patients underwent V.A.T.S. thymectomy. There was no peri-operative mortality. Radiotherapy in the adjuvant setting was used in the 78% patients with Masaoka Stges II-IV.Conclusion: Thymomas are relatively uncommon. Their varied histology and clinical behavior have made development of de" nitive treatment algorithms dif" cult. When possible resection offers the best treatment. Minimally invasive thoracoscopic excision seems especially attractive in the small tumours. Keywords: Thymoma, Myaesthenia Gravis , V.A.T.S.
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